IMMUNOMETABOLISM Tumor necrosis factor induces
RIP3 and one of its substrates, PGAM5, in-creases mitochondrial reactive oxygen species (mROS) such as superoxide and hydrogen peroxide in infected macrophages (fig. S1) (5, 6). These mROS activate an interorganel-lar signaling circuit that involves the lyso-some and the endoplasmic reticulum. This ultimately causesmitochondrialcalcium over-
Mitophagy in degenerative joint diseases - PubMed
Mitochondrial dysfunction is involved in aging and multiple degenerative diseases, including intervertebral disc degeneration (IVDD) and osteoarthritis (OA). Thus, the maintenance of mitochondria homeostasis and function is important. Mitophagy, a process that selectively clears damaged or dysfuncti
Organelle-specific autophagy in inflammatory diseases: a
The structural integrity and functional stability of organelles are prerequisites for the viability and responsiveness of cells. Dysfunction of multiple organelles is critically involved in the pathogenesis and progression of various diseases, such as chronic obstructive pulmonary disease, cardiovascular diseases, infection, and neurodegenerative diseases.
A regulatory signaling loop comprising the PGAM5 phosphatase and CK2 controls receptor-mediated mitophagy. Molecular Cell 2014, 54(3):362-77 (* 通讯作者,IF=15, 他引 319) (11) Ma B, Cheng H, Gao R, Mu C, Chen L, Wu S, Chen Q, Zhu Y*. Zyxin-Siah2-Lats2 axis mediates cooperation between Hippo and TGF-beta signalling pathways.
细胞死亡的11种姿势 - 知乎
Oxeiptosis是氧自由基诱导的不依赖半胱天冬酶的新型RCD，该过程由KEAP1-PGAM5-AIFM1途径驱动。 过度活化的KEAP1可以NFE2L2非依赖性方式介导H2O2诱导的Oxeiptosis，通过KEAP1-PGAM5途径介导AIFM1 Ser116的去磷酸化。 Oxeiptosis在人类疾病中的作用仍然未知。
蒋辉 博士 - 科学研究 - 北京生命科学研究所
Phone：86-10-80726688-8620 Fax： 86-10-80726671 E-mail：jianghui@nibs
InterVar-Genetic variants Interpretation by ACMG/AMP 2015
Based on the ACMG/AMP 2015 guidelines, the criteria fall into two sets: pathogenic/likely pathogenic (P/LP) and benign/likely benign (B/LB)e are a total of 28 criteria: for the P/LP criterion, there are 16 criteria as very strong (PVS1), strong (PS1-4); moderate (PM1-6), or supporting (PP1-5); for the B/LB criterion, there are 12 criteria as stand-alone (BA1), strong
Pathway Search Result - KEGG
Entry Thumbnail Image Name Description Object Legend; hsa00010: Glycolysis / Gluconeogenesis: Glycolysis is the process of converting glucose into pyruvate and generating small amounts of ATP (e..
Protein phosphatase - Wikipedia
A protein phosphatase is a phosphatase enzyme that removes a phosphate group from the phosphorylated amino acid residue of its substrate protein. Protein phosphorylation is one of the most common forms of reversible protein posttranslational modification (), with up to 30% of all proteins being phosphorylated at any given timeein kinases (PKs) are the effectors of
Mechanisms of mitophagy in cellular homeostasis, physiology and
Aug 28, 2018Mitochondrial phosphatase PGAM5 dephosphorylates FUNDC1, thereby disrupting its physical association with OPA1 and inhibiting